External validation of the PROFUND index in polypathological patients from internal medicine and acute geriatrics departments in Aragón

dianagosalvez Diana Gosálvez Prados last modified 21/12/2015 12:55

The objective of the study was to validate externally and prospectively the PROFUND index to predict survival of polypathological patients after a year.

Diez-Manglano J, Garcia JLC, Calvo EGA, Sainz AJ, Begueria EC, Martinez-Alvarez RM, Tello EB, Martinez AC. External validation of the PROFUND index in polypathological patients from internal medicine and acute geriatrics departments in Aragón. Internal and emergency medicine,10 (8):915-926. Available at: http://link.springer.com/article/10.1007/s11739-015-1252-2


Article

21/12/2015

An observational, prospective and multicenter study was performed. Polypathological patients admitted to an internal medicine or geriatrics department and attended by investigators consecutively between March 1 and June 30, 2011 were included. Data concerning age, gender, comorbidity, Barthel and Lawton-Brody indexes, Pfeiffer questionnaire, socio-familial Gijon scale, delirium, number of drugs and number of admissions during the previous year were gathered for each patient. The PROFUND index was calculated. The follow-up lasted 1 year. A Cox proportional regression model was calculated, and was used to analyze the association of the variables to mortality and C-statistic. 465 polypathological patients, 333 from internal medicine and 132 from geriatrics, were included. One-year mortality is associated with age [hazard ratio (HR) 1.52 95 % CI 1.04-2.12; p = 0.01], presence of neoplasia [HR 2.68 95 % CI 1.71-4.18; p = 0.0001] and dependence for basic activities of daily living [HR 2.34 95 % CI 1.61-3.40; p = 0.0009]. In predicting mortality, the PROFUND index shows good discrimination in patients from internal medicine (C-statistics 0.725 95 % CI 0.670-0.781), but a poor one in those from geriatrics (0.546 95 % CI 0.448-0.644). The PROFUND index is a reliable tool for predicting mortality in internal medicine PP patients.


Diez-Manglano J, Garcia JLC, Calvo EGA, Sainz AJ, Begueria EC, Martinez-Alvarez RM, Tello EB, Martinez AC.

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