New drugs and patient-centred end-points in old age: setting the wheels in motion.
Older patients with various degrees of frailty and disability, a key population target of pharmacological interventions in acute and chronic disease states, are virtually neglected in pre-marketing studies assessing the efficacy and safety of investigational drugs.
Mangoni AA, Pilotto A. New drugs and patient-centred end-points in old age: setting the wheels in motion. Expert Rev Clin Pharmacol. 2016 Jan;9(1):81-9. Available at: http://www.tandfonline.com/doi/abs/10.1586/17512433.2016.1100074?journalCode=ierj20
Mangoni AA, Pilotto A.