Neuropathological Correlates of Cerebral Multimorbidity.

Vivian Vivian Benítez Hidalgo última modificación 16/07/2013 09:38

Age associated neurodegenerative diseases are characterized by intra- and extracellular aggregation and deposition of misfolded proteins. The neuropathological classification of neurodegenerative diseases is based on the semi-qunatitative assessment of these misfolded proteins, that constitute the neuropathological hallmark lesion for the respective disease: e.g. Alzheimer's disease (AD), amyloid-? (A?) hyperphosphorylated tau (tau); Lewy body diseases, ?-synuclein (?-syn); frontotemporal lobar degeneration, tau or TDP-43 or ubiquitin or FUS. In addition, cerebovascular lesions are assessed for the diagnosis of vascular dementia. However, in brains of elderly patients suffering from neurodegenerative diseases multiple pathologies are usually present and even in clinically characterized prospective cohorts additional pathologies are frequently found at post mortem examination. On the other hand, various amounts of AD pathology are frequently seen in brains of non-demented elderly and the threshold to cause clinical overt dementia is ill defined as additional co-morbidities (e.g., cerebrovascular lesions) might lower the threshold for clinical dementia in some cases

Attems J, Jellinger K. Neuropathological Correlates of Cerebral Multimorbidity. Curr Alzheimer Res. Apr 29 2013.


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16/07/2013
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Attems J, Jellinger K.

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