What do we need to know?

General  

• What are the health trajectories and life conditions that result in multiple comorbidity and complex chronic disease?
• What are the most effective individual and populational approaches to prevention?
• What are the approaches in terms of conceptualizing prevention in the chronic disease literature that can be applied to polypathology?
• What is new or different about the polypathological population?
• What research questions is it important for us to pursue?
• What is the relative contribution of primordial, primary, secondary and tertiary prevention in improving outcomes and satisfaction, and reducing costs in people living with multiple diseases? What is the best prevention strategy to pursue in any given set of circumstances?
• Can we produce a guide that could be used in very different circumstances?

The following is a list of research and policy questions for primordial, primary and
secondary prevention.